Sherman was locked in a fierce but friendly battle with Carolina Panthers quarterback Cam Newton for the coveted honor, voted on in an online poll at ESPN.com.
"Winning the cover is a kid's dream come true," Sherman tells ESPN. "I would never be in the position without my fellow Legion of Boom members and teammates."
Sherman is only the third defensive player to make the cover of the popular video game, joining Baltimore linebacker Ray Lewis in 2005 and Pittsburgh safety Troy Polamalu, who shared the 2010 cover with Arizona wide receiver Larry Fitzgerald.
Sherman becomes the second Seahawks player to earn the honor. Running back Shaun Alexander was the Madden cover athlete in 2007.
While some think a jinx comes with the cover, Sherman campaigned hard for what's considered a prestigious honor among NFL players.