FDA chief says long-awaited opioid review still in the works

Aug 29, 2022, 9:11 PM | Updated: Aug 30, 2022, 2:49 pm


AP Photo/Mark Lennihan, File)

WASHINGTON (AP) — A long-awaited review of prescription opioid medications, including their risks and contribution to the U.S. overdose epidemic, is still underway at the Food and Drug Administration, the agency’s commissioner said Tuesday.

Dr. Robert Califf wrote in a blog entry that the FDA is still studying “what revisions are needed to support appropriate use” of opioid painkillers and “lessons learned” by the agency. The update comes as part of a broader outline of the FDA’s ideas and initiatives for combating drug misuse and addiction.

Califf told The Associated Press that the sheer scale of the epidemic makes potential remedies a challenge.

“Almost everything that we want to do involves some other entity or part of society that we need to work with to figure things out,” Califf said in an interview Tuesday.

Califf promised to conduct a full review of FDA’s approach to opioids, including their prescribing instructions, to clinch Senate confirmation early this year. He told the AP last month that the public would soon hear “a lot more about this.”

Part of the delay in reassessing the drugs is that makers of long-acting opioids didn’t originally study the medications’ effectiveness for long-term pain, which carries risks of addiction and overdose. FDA-mandated studies to get at that question have dragged on for years.

“FDA does its best when it has high quality evidence, and we don’t have high quality evidence now,” Califf said, adding that it may ultimately take government-run studies to answer the question of long-term opioid safety and effectiveness.

Tuesday’s update is also unlikely to appease Califf’s critics in Congress, including five Senate Democrats who voted against his nomination, largely over concerns that the FDA hasn’t taken bolder action to reduce opioid prescribing and misuse.

It’s not the first attempt at a reset on opioids for the FDA — or even for Califf. During his brief stint as FDA commissioner at the end of the Obama administration, Califf had also vowed to conduct a “sweeping review” of opioids.

Dr. Andrew Kolodny, an FDA critic who has testified against drugmakers in court, said Califf must do more than review FDA’s “lessons learned” on opioids.

“He also needs to take on the heavier lift of correcting past mistakes” by removing unproven medications from the market, said Kolodny, who leads a group that favors tighter opioid prescribing.

Last year, U.S. overdose deaths soared to a record of 107,000, driven overwhelmingly by fentanyl and other illegal opioids. Opioid prescriptions have fallen about 40% in the last decade but deaths tied to the medications remain at 13,000 to 14,000 per year.

Califf’s post lays out a framework for combating drug addiction and overdoses overall, focusing on reducing inappropriate prescribing, developing new addiction and overdose therapies and shutting down suppliers of illicit drugs.

But many of the agency’s specific ideas have failed to gain traction.

For example, a recent FDA proposal that would require pharmacies to dispense “mail-back” envelopes with every opioid prescription has faced resistance from pharmacists, drugmakers and other groups. Elsewhere the FDA has tried for nearly a decade to require doctors and other health professionals to undergo training in safe opioid prescribing. That effort has been stalled over questions of whether it requires action by Congress or other government agencies. Medical societies generally oppose any blanket requirement.

Califf said the FDA continues to work with other federal officials to find a way to implement broader training.

“I’m personally in favor of mandatory education,” Califf said, but it must match “the needs of the clinicians, which I think is very hard to do.”

Califf said another priority will be encouraging the development of an over-the-counter version of naloxone, the medication that can reverse opioid overdose. Most states have passed measures allowing pharmacists to dispense the drug without a prescription, but an over-the-counter version would further expand access.

Even that proposal could have unintended consequences, if consumers are unable to afford naloxone that’s no longer covered by insurance.

“We know that more naloxone is needed,” Califf said. “The question is how to do that.”


The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

Copyright © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


Image:The New York Giants' Willie Mays poses for a photo during baseball spring training in 1972. M...

Associated Press

Willie Mays, Giants’ electrifying ‘Say Hey Kid,’ dies at 93

Willie Mays, whose singular combination of talent, drive and exuberance made him one of baseball’s greatest players, has died. He was 93.

1 day ago

Image: This photo provided by the Washington Department of Ecology shows a derailed BNSF train on t...

Associated Press

Judge orders BNSF to pay Washington tribe nearly $400M for trespassing with oil trains

BNSF Railway must pay the sum to a Native American tribe in Washington after it ran 100-car trains with crude oil on the tribe's reservation.

2 days ago

Photo: In this photo provided by Tieanna Joseph Cade, an amusement park ride is shown stuck with 30...

Associated Press

Crews rescue 28 people trapped upside down high on Oregon amusement park ride

Emergency crews in Oregon rescued 28 people after they were stuck dangling upside down high on a ride at a century-old amusement park.

2 days ago

juneteenth shooting texas...

Associated Press

2 killed and 6 wounded in shooting during a Juneteenth celebration in a Texas park

A shooting in a Texas park left two people dead and six wounded, including two children, on Saturday, authorities said.

4 days ago

Photo: Israeli soldiers drive a tank near the Israeli-Gaza border, in southern Israel, Wednesday, J...

Jack Jeffery, The Associated Press

8 Israeli soldiers killed in southern Gaza in deadliest attack on Israeli forces in months

An explosion in Gaza killed eight Israeli soldiers, the military said Saturday, making it the deadliest attack on Israeli forces in months.

4 days ago

Juanita Beach Kirkland...

Kathy McCormack and Nick Perry, The Associated Press

‘Tis the season for swimming and bacteria alerts in lakes, rivers

With summer about to start, many people flocking to their favorite swimming holes may also want to read up on bacteria warnings.

5 days ago

FDA chief says long-awaited opioid review still in the works