RACHEL BELLE

Seattle drug company working on non-addictive, non-opioid painkiller

Jun 20, 2017, 5:30 AM | Updated: 10:59 am
opioid...
Photo by The Javorac, CC Images.
LISTEN: Seattle drug company working on non addictive, non opioid pain killer

According to a recent report by the New York Times, drug overdoses are now the leading cause of death for Americans under the age of 50. The Times reports 19 percent more drug overdose deaths in 2016 than in 2015 and the numbers for 2017 continue to rise.

Many of these deaths are the result of opioid painkillers, which is why Seattle drug company Kineta is developing a non-opioid painkiller with no addictive qualities.

“It doesn’t have a generic name yet so we call it KCP-400,” Kineta’s CEO, Shawn Iadonato, explained. “It’s a non-opioid for the treatment of pain. It’s different than things like morphine, OxyContin, things like that. What’s real exciting about the drug is it’s very effective pain treatment but it also has anti-inflammatory and neuroprotective effects.”

Kineta’s vice president of Research and Development, Kristin Bedard, says there’s nothing quite like it on the market now.

“KCP-400 will be the first in this class of drugs,” she said. “It is very unique because not only is it analgesic, which means that it can relieve the pain, but it has these disease modifying effects. So it can really treat, not just the symptoms, but what’s causing the chronic pain.”

Iadonato says it can treat ailments such as lower back pain, diabetic peripheral neuropathy and chemotherapy induced neuropathies for cancer patients.

“Those are the types of pain that are longer term pain that are really harder to treat with opioids because opioids typically stop working after a while. People need to take more, they develop tolerance and it becomes riskier and riskier to the patient,” Iadonato said.

Bedard explains why KCP-400 does not have the addictive quality other opioid painkillers do.

“The drug targets the peripheral nervous system,” Bedard said. “So it targets where a patient has the occurrence of pain but it doesn’t go to the brain so you don’t have those issues with side effects, addiction, that type of thing.”

The drug originates from snails.

“It was originally identified in a cone snail that grows off the coast of the Caribbean,” Iadonato said. “Now it’s a fully synthetic product. Maybe half the drugs that we take come from natural products. Animal venoms are a really rich source of drugs. It’s a poison to the fish that the [snail] hunts. The snail has a little spear that it shoots at the fish and that paralyzes the fish and gives the snail time to eat it.”

To give you an idea of how many addictive opioid painkillers are out there:

“I think last year there were 260 million opioid prescriptions written so that’s essentially one prescription for every adult in the United States,” Iadonato said.

KCP-400 has been performing well on animals and next year it will go into human trials. It’s still about four or five years away from being approved to hit the market.

  • listen to rachel belleTune in to KIRO Radio on weekdays to hear Rachel Belle.
Who is Rachel Belle?

Your Last Meal

Rachel Belle

supply chain...
Rachel Belle

Start your holiday shopping now or risk supply chain issues

Now is the time to start holiday gift shopping because if you don't buy soon, supply chain issues may make it tough to get what you want later.
19 days ago
Dick's...
Rachel Belle

How does Dick’s Drive-In pay workers $19 an hour with a menu completely under $5?

Dick's Drive-In recently raised its base pay, as did Taco Time, which is now offering employees $20 an hour at select locations. How do they keep prices low and pay high?
20 days ago
botox...
Rachel Belle

Don’t like how you look on Zoom? Many young Americans are now getting Botox

More people are turning to Botox to get rid of lines and wrinkles, but is it safe? How does one age naturally in a youth obsessed country? Experts weigh in.
26 days ago
certified wildlife habitat...
Rachel Belle

Turn your backyard into a Certified Wildlife Habitat

The National Wildlife Federation will help you make your yard a habitable home for bees, birds, bugs and critters. And they'll give you an official sign!
1 month ago
Emily Cherkin and Ben Gitenstein, pictured months after 9/11. (Photo courtesy of Emily Cherkin)...
Rachel Belle

‘You either got married or broke up’: 20 years later, a Seattle couple on falling in love in NYC in the wake of 9/11

On Sept. 11, 2001, Seattle's Emily Cherkin and Ben Gitenstein were 22 years old and separately taking the subway into Manhattan when two planes crashed into the Twin Towers. This is their story.
2 months ago
dirty work...
Rachel Belle

New book ‘Dirty Work’ reveals psychological toll of working unsavory jobs nobody wants

A new book by Eyal Press called "Dirty Work: Essential Jobs and the Hidden Toll of Inequality in America" takes a deeper look at jobs no one wants to do.
2 months ago

Sponsored Articles

...

Medicare open enrollment for 2022 starts Oct. 15 and SHIBA can help!

Washington State Office of the Insurance Commissioner SPONSORED — Medicare’s Open Enrollment Period, also called the Annual Election Period, is Oct. 15 to Dec. 7. During this time, people enrolled in Medicare can: Switch from Original Medicare to a Medicare Advantage plan and vice versa. Join, drop or switch a Part D prescription drug plan, […]
...

How to Have a Stress-Free Real Estate Experience

The real estate industry has adapted and sellers are taking full advantage of new real estate models. One of which is Every Door Real Estate.
...
IQ Air

How Poor Air Quality Is Affecting Our Future Athletes

You cannot control your child’s breathing environment 100% of the time, but you can make a huge impact.
...
Swedish Health Services

Special Coverage: National Prostate Cancer Awareness Month

There are a wide variety of treatment options available for men with prostate cancer. The most technologically advanced treatment option in the Northwest is Stereotactic Body Radiation Therapy using the CyberKnife platform.
...
Marysville Police Department

Police Opportunities in a Growing, Supportive Washington Community

Marysville PD is looking for both lateral and entry level officers. Begin or continue your career in law enforcement for a growing, supportive community.
...
Comcast

Small, Minority-Owned Businesses in King County and Pierce County Can Now Apply For $10,000 Relief Grants Through Comcast RISE

Businesses in King County and Pierce County can apply beginning on October 1, 2021, at www.ComcastRISE.com for a chance to receive a $10,000 relief grant.
Seattle drug company working on non-addictive, non-opioid painkiller